King Ferdinand II of Aragon and Queen Isabella I of Castille.
Maria of Aragon, Queen of Portugal - Source picture: Wikipedia
Maria of Aragon was as infanta of Spain very important for marriage.
Finally she married King Manuel I of Portugal on October 30th. 1500.
They had 10 children, 8 of them reached adulthood.
Maria died on March 7th. 1517 in Lisbon. She only became 34 years.